Cancer Research UK, London Research Institute, London, UK
Barry’s research focuses on a signaling pathway known as Hippo. Defective components in the pathway cause the formation of large tumours in flies. Together with his research team he has developed techniques to study the Hippo and other pathways in living animals. Using RNAi technology Barry’s team can turn down the activity of genes that make the Hippo pathways components to investigate their effects on development.
The Cancer Research UK London Research Institute (CRUK-LRI) aims to improve our understanding of cancer. Across some 50 CRUK laboratories, researchers study the biology of tissues and organs; molecular cell biology; the cell cycle; and chromosome and DNA repair. Barry was recently recruited to the study cancer biology using the fruit fly Drosophila as a model system
Barry’s team: the Epithelial Biology Laboratory is now working in collaboration with the Vienna Drosophila RNAi Screening Centre (VDRC), headed by Dr Krystyna Keleman, and with Barry Dickson’s lab to conduct an in vivo genome-wide RNAi screen to identify novel molecular regulators of cancer-relevant processes in the fly.