European Molecular Biology Laboratory, Heidelberg, Germany
Wolfgang leads a computational biology research group in the European Molecular Biology Laboratory (EMBL). He has appointments at the Genome Biology Unit in Heidelberg and at the European Bioinformatic Institute (EBI), one of the world's largest bioinformatics service providers, in Cambridge. His group studies genotypes and phenotypes on a genome-wide scale: how do variations in the genomes of individuals shape their complex phenotypes? To this end, they develop computational methods in statistics, signal and image processing.
They work together with experimental laboratories in systems genetics and functional genomics to develop the best methods for designing and analysing genome-wide experiments whose aim is to unravel the mechanisms of genetic inheritance, gene expression, signal transduction and how they shape phenotype. Most phenotypes, including human diseases, are complex: they are governed by large sets of genes and regulatory elements. Wolfgang's aim is to map these complex networks and eventually, to devise strategies for designing phenotypes by engineering combinatorial perturbations.
Wolfgang's research is driven by new technologies, and he employs data from high-throughput sequencing (ChIP-Seq, RNA-Seq), tiling microarrays, large scale cell based assays, automated microscopy, as well as the most advanced methods of computational statistics. He is a core member of the Bioconductor project, a leading platform for the development and publication of software for functional genomics data analysis and modelling.