Seventh Framework Programme - European Union
An EU consortium to identify novel targets and drugs for cancer treatment

Publications

 

Lancaster OM, Le Berre M, Dimitracopoulos A, Bonazzi D, Zlotek-Zlotkiewicz E, Picone R, Duke T, Piel M, Baum B. (2013). Mitotic rounding alters cell geometry to ensure efficient bipolar spindle formation. Dev Cell. 25(3):270-83.

Da Ros VG, Gutierrez-Perez I, Ferres-Marco D, Dominguez M. (2013). Dampening the Signals Transduced through Hedgehog via MicroRNA miR-7 Facilitates Notch-Induced Tumourigenesis. PLoS Biol. 11(5):e1001554.

Schmidt EE, Pelz O, Buhlmann S, Kerr G, Horn T, Boutros M. (2013). GenomeRNAi: a database for cell-based and in vivo RNAi phenotypes, 2013 update. Nucleic Acids Res. 41 (Database issue):D1021-6.

Garelli A , Gontijo AM, Miguela V, Caparros E, Dominguez M. (2012). Imaginal discs secrete insulin-lile peptide 8 to mediate plasticity of growth and maturation. Science. 336(6081):579-582.

Matthews HK, Delabre U, Rohn JL, Kunda P, Guck J, Baum B. (2012). Changes in ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression. Developmental Cell, 23 (2):371-383.

Ntziachristos P, Tsirigos A, ... Ferres-Marco D, da Ros V, ... Dominguez M, Ferrando A, Aifantis I. (2012). Genetic inactivation of polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nat Med. 18(2):298-301.

Kunda P, Rodrigues NT, Moeendarbary E, Liu T, Ivetic A, Charras G, Baum B. (2012). PP1-mediated moesin dephosphorylation couples polar relaxation to mitotic exit. Curr Biol,. 22(3):231-236.

Axelsson E, Sandmann T, Horn T, Boutros M, Huber W, Fischer B. (2011). Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi. BMC Bioinformatics. 12(1):342.

Horn T, Sandmann T, Fischer B, Axelsson E, Huber W, Boutros M. (2011). Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Nat Methods. 8(4):341-6.

Schnorrer F, Schönbauer C, Langer CC, Dietzl G, Novatchkova M, Schernhuber K, Fellner M, Azaryan A, Radolf M, Stark A, Keleman K, Dickson BJ. (2011). Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Nature.464(7286):287-91.

Gontijo AM, Miguela V, Whiting MF, Woodruff RC, Dominguez M. (2011). Intron retention in the Drosophila melanogaster Rieske Iron Sulphur Protein gene generated a new protein. Nat Commun. 2:323.

Ragab A, Buechling T, Gesellchen V, Spirohn K, Boettcher AL, Boutros M. (2011). Drosophila Ras/MAPK signalling regulates innate immune responses in immune and intestinal stem cells. EMBO J. 30(6):1123-36.

Vallejo DM, Caparros E, Dominguez M. (2011). Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. EMBO J. 30(4):756-69.

Horn T, Sandmann T, Boutros M. (2010). Design and evaluation of genome-wide libraries for RNA interference screens. Genome Biol. 11(6):R61.

Bina S, Wright VM, Fisher KH, Milo M, Zeidler MP. (2010). Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation. EMBO Rep. 11(3):201-7.

Pau G, Fuchs F, Sklyar O, Boutros M, Huber W. (2010). EBImage - an R package for image processing with applications to cellular phenotypes. Bioinformatics. 26(7):979-81.

Bourgon R, Gentleman R, Huber W. (2010). Independent filtering increases detection power for high-throughput experiments. Proc Natl Acad Sci USA. 107(21):9546-51.

Gutierrez-Aviño FJ, Ferres-Marco D, Dominguez M. (2009). The position and function of the Notch-mediated eye growth organizer: the roles of JAK/STAT and four-jointed. EMBO Rep. 10(9):1051-8.

Grusche FA, Hidalgo C, Fletcher G, Sung HH, Sahai E, Thompson BJ. (2009). Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]. BMC Dev Biol. 9:14.

Liu T, Sims D, Baum B. (2009). Parallel RNAi screens across different cell lines identify generic and cell-type specific regulators of actin organisation and cell morphology. Genome Biol.;10(3):R26.

Sims D, Duchek P, Baum B. (2009). PDGF/VEGF signaling controls cell size in Drosophila. Genome Biol. 12;10(2):R20.

Xu Z., Wei W., Gagneur J., Perocchi F., Clauder-Münster S., Camblong J., Guffanti E., Stutz F., Huber W., Steinmetz L.M. (2009). Bidirectional promoters generate pervasive transcription in yeast. Nature 457(7232): 1033-1037.

Basanta D, Miodownik M, Baum B. (2008). The evolution of robust development and homeostasis in artificial organisms. PLoS Computational Biology 4(3), e1000030.

Boutros M. and Ahringer, J. (2008). The art and design of genetic screens: RNA interference. Nature Rev. Genet., 9:554-566.

Dominguez M. and F. Berger (2008). Chromatin and Cell Cycle Meeting in Madrid. Development. Nov;135(21):3475-80. MEETING REPORT

Georgiou M., Marinari E., Burden J., Baum B. (2008). Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability. Curr Biol.18(21):1631-8.

Mancera E., Bourgon R., Brozzi A., Huber W., Steinmetz L.M. (2008). High-resolution mapping of meiotic crossovers and non-crossovers in yeast. Nature 454(7203): 479-485.

Weber U., Pataki C., Mihaly J. and Mlodzik M. (2008). Combinatorial signaling by the Frizzled/PCP and Egfr pathways during planar cell polarity establishment in the Drosophila eye. Dev. Biol. 316:(1) 110-123.

Dietzl G, Chen D, Schnorrer F, Su KC, Barinova Y, Fellner M, Gasser B, Kinsey K, Oppel S, Scheiblauer S, Couto A, Marra V, Keleman K, Dickson BJ (2007). A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 448(7150):151-6.

Palomero T., Sulis M. L., Cortina M., Real P. J., Barnes K., Ciofani M., Caparros E., Buteau J., Brown K., Perkins S. L., Bhagat G., Mishra A., Basso G., Parsons R., Zúñiga-Pflücker J. C., Dominguez M., and Adolfo A. Ferrando (2007). Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nature Medicine 13(10):1203-10.